*These terms are defined and utilized in this text as applied to the principles of Judicious Use outlined within this document.
Antibiotic--a chemical substance produced by a microorganism which has the capacity, in dilute solutions, to inhibit the growth of or to kill other microorganisms.
Antimicrobial--an agent that kills microorganisms or suppresses their multiplication or growth.
Breakpoint-- a minimum inhibitory concentration (as determined by the Veterinary Antimicrobial Susceptibility Testing subcommittee of the Clinical and Laboratory Standards Institute) selected to predict clinical outcome for a specific veterinary pathogen, in a specific disease, in a specific species, given a specific regimen (dose, route, duration, and frequency) and used to define bacteria isolated from animals as susceptible, intermediate, or resistant.
Broad Spectrum Antimicrobial--a type of antimicrobial effective against a large number of bacterial genera; generally describes antimicrobials effective against both Gram-positive and Gram-negative bacteria.
Narrow Spectrum Antimicrobial--a type of antimicrobial effective against a limited number of bacterial genera; often applied to an antimicrobial active against specific families or categories of bacteria.
Antimicrobial Resistance--a property of microorganisms that confers the ability to inactivate or elude antimicrobials or a mechanism that blocks the inhibitory or killing effects of antimicrobials.
Extralabel Use--extralabel use describes the use of an approved drug in a manner that is not in accordance with the approved labeling, yet meets the conditions set forth by the AMDUCA FDA regulations. Deviations from FDA-approved labeling include use in another species, use for a different indication, use at a different dose or frequency, and use via a different route of administration.
Monitoring--monitoring includes periodic health surveillance of the population or individual animal examination.
Selection Pressure-- action or play of selection mechanisms (eg, differential mortality or reproduction rates) determining the relative reproductive performance of genotypes, where selection is the differential and nonrandom survival and reproduction of individuals of different genotypes, resulting in a change in the gene frequency in succeeding generations in a population of a given organism.
Therapeutic--treatment, control, and prevention of disease.
Veterinarian/Client/Patient Relationship (VCPR) --The VCPR is the basis for interaction among veterinarians, their clients, and their patients. A VCPR means that all of the following are required: