The AVMA supports the development and promulgation of antimicrobial use guidelines for companion animal practitioners as a resource to improve antimicrobial stewardship in companion animal practice. Guidelines such as these should not be construed as dictating an exclusive course of treatment or procedure. Variations in practice may be warranted based on factors unique to the patient, client, or veterinary practice, in accordance with best clinical judgment. Members should recognize that there may be variability in the availability and recommended use of certain antimicrobial drugs among countries. In addition, recommendations may change as further information becomes available over time. Therefore, any such guidelines should be reviewed by the issuing body at least every 5 years and updated as necessary.