February 15, 2008


 New swine flu subtype has avian flu genes

Posted Feb. 1, 2008

Researchers have identified a new strain of swine influenza, H2N3, which belongs to the group of H2 influenza viruses that last infected humans during the 1957 pandemic. This new strain has a molecular twist—it is composed of avian and swine influenza genes.

Agricultural Research Service veterinarians, Drs. Juergen Richt, Amy Vincent, Kelly Lager, and Phillip Gauger, conducted this research with Iowa State University visiting scientist Wenjun Ma; ISU veterinary pathologist, Dr. Bruce Janke; and other colleagues at the University of Minnesota and St. Jude Children's Research Hospital. The ARS veterinarians work at the agency's National Animal Disease Center in Ames, Iowa.

The research team studied an unknown pathogen that infected two groups of pigs at separate production facilities in 2006. Both groups used water obtained from ponds frequented by migrating waterfowl.

Molecular studies indicated the pathogen was an H2N3 influenza virus that is closely related to an H2N3 strain found in mallard ducks. This was the first time it was observed in mammals.

Influenza viruses have eight gene segments, all of which can be swapped between various virus strains. Two of these gene segments code for virus surface proteins that help determine whether an influenza virus is able to infect a specific host and start replicating—the first step in the onset of influenza infection.

In the newly isolated swine H2N3, the avian H2 and N3 gene segments mixed with gene segments from common swine influenza viruses. This exchange and additional mutations gave the H2N3 viruses the ability to infect swine. Laboratory tests confirmed that this strain of H2N3 could also infect mice and ferrets.

The findings provide further evidence that swine have the potential to serve as a "mixing vessel" for influenza viruses carried by birds, pigs, and humans. They also support the need to continue monitoring swine and livestock workers for H2-subtype viruses and other influenza strains that might someday threaten swine and human health.

Results of this study were published Dec. 26, 2007 (Vol. 194, No. 52), in the Proceedings of the National Academy of Sciences of the United States of America.