The AVMA supports the monitoring of vaccine safety and efficacy via a publicly available central reporting system. The system should collect reports of all vaccine associated adverse events including any perceived failures in safety and/or efficacy. The reporting system should be user-friendly and readily available to facilitate adverse event reporting by veterinary practitioners. The reports should follow a standardized, systematic template. Any compilation or interpretation of these reports should be provided in a form that is useful to biological firms and clinically relevant for veterinarians. Implementation of the central reporting system needs to be a high priority for the USDA-APHIS Center for Veterinary Biologics and adequate funding must be provided. The need for vaccinovigilance is significant and urgent to ensure that animal health, public health and food safety are protected.