The AVMA recognizes that animals play a central and essential role in research, testing, and education for continued improvement in the health and welfare of human beings and animals. The AVMA also recognizes that humane care of animals used in research, testing, and education is an integral part of those activities. In keeping with these concerns, the AVMA endorses the principles embodied in the "Three R" tenet of Russell and Burch (1959). These principles are: refinement of experimental methods to eliminate or reduce animal pain and distress; reduction of the number of animals consistent with sound experimental design; and replacement of animals with non-animal methods wherever feasible.

The use of animals in research, testing, and education is a privilege carrying with it unique professional, scientific, and moral obligations, and ethical responsibilities. The AVMA encourages proper stewardship of all animals, but defends and promotes the use of animals in meaningful research, testing, and education programs.

The AVMA condemns all acts of violence, vandalism, or intimidation directed toward individuals, facilities, or tertiary organizations affiliated with the use of animals in research, testing, or education.